In 2017, Louisiana’s Pregnancy-Associated Mortality Review Report identified substance use as one of the leading causes of pregnancy-associated deaths among pregnant and postpartum people. In September 2021, the Louisiana Perinatal Quality Collaborative (LaPQC) began implementation of the AIM Obstetric Care for Women with Opioid Use Disorder Patient Safety Bundle among 11 of the state’s 47 birthing facilities. Between January and December 2022, universal screening increased from 70% to 72%; referral to treatment for those who screened positive increased from 36% to 48%; and referral to medication for opioid use disorder (MOUD) increased from 29% to 34%. The LaPQC continues to work with participating facilities to provide evidence-informed, respectful care to pregnant and postpartum patients with substance use conditions and their families.